methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate
CAS No.:959999-77-0
Molecular Formula:C₂₃H₂₁ClN₂O₅S₂
Molecular Weight:505.015
Hs Code.:

Synonyms:methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

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Chemical Property of methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

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Technology Process of methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

There total 2 articles about methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 929095-64-7
methyl 5-[6-(chloromethyl)-1H-benzimidazol-1-yl]-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate

: 2386-57-4
methanesulfonic acid sodium salt

: 959999-77-0
methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

Guidance literature:: In ethanol; at 85 ℃; for 16h;

Reference yield:

: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[6-(hydroxymethyl)-1H-benzimidazol-1-yl]-2-thiophenecarboxylate

: 959999-77-0
methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 0.33 h / Heating / reflux

2: ethanol / 16 h / 85 °C

With N-chloro-succinimide; triphenylphosphine; In ethanol; dichloromethane;

Reference yield:

: 959999-77-0
methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate

: 3-(((1R)-1-(2-chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)phenyl)ethyl)oxy)-5-(6-((methylsulfonyl)methyl)-1H-benzimidazol-1-yl)-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 40 °C

2: di-tert-butyl-diazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / 24 h

3: cesium fluoride / methanol / 4 h / 60 °C

4: caesium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

5: trifluoroacetic acid / dichloromethane / 1 h

6: sodium tris(acetoxy)borohydride / methanol; dichloromethane / 0.5 h / 20 °C

7: ammonia / methanol / 40 h / 80 °C

With di-tert-butyl-diazodicarboxylate; ammonia; sodium tris(acetoxy)borohydride; caesium carbonate; cesium fluoride; trifluoroacetic acid; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;