2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

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Chemical Name:2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide
CAS No.:1489134-86-2
Molecular Formula:C₃₁H₃₀N₆O₄S
Molecular Weight:582.683
Hs Code.:

Synonyms:2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

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Chemical Property of 2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

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Technology Process of 2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

There total 6 articles about 2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 1489134-76-0
3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoic acid

: 1489134-86-2
2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

Guidance literature:: 3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.0833333h; Inert atmosphere;

1-(4-Nitrophenyl)piperazine; With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.08.024

Reference yield:

: 1489134-73-7
ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

: 1489134-86-2
2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 1 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.08.024

Reference yield:

: 1489134-62-4
2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylic acid

: 1489134-86-2
2-methyl-N-(3-(4-(4-nitrophenyl)piperazin-1-yl)-3-oxopropyl)-4-phenyl-4H-benzo [4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 1 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.08.024