(S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate
• CAS No.: 1643771-03-2
• Molecular Formula: C₃₀H₂₇N₃O₆
• Molecular Weight: 525.561
• Mol file: 1643771-03-2.mol

Synonyms:(S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate

Chemical Property of (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate

There total 3 articles about (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-hydroxy-2,2-dimethyl-1-(2-phenylacetyl)imidazolidin-4-one (1643771-07-6) + Nα-phthaloyl-L-phenylalanine (5123-55-7) → (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate (1643771-03-2)

Guidance literature:

Nα-phthaloyl-L-phenylalanine; With diisopropyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

3-hydroxy-2,2-dimethyl-1-(2-phenylacetyl)imidazolidin-4-one; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201402818

Reference yield:

3-(benzyloxy)-2,2-dimethyl-1-(2-phenylacetyl)imidazolidin-4-one (1643771-06-5) → (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate (1643771-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen; 10 wt% Pd(OH)2 on carbon / water; ethanol / 20 °C

2.1: diisopropyl-carbodiimide / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With 10 wt% Pd(OH)2 on carbon; hydrogen; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; water;

DOI:10.1002/chem.201402818

Reference yield:

phenylacetyl chloride (103-80-0) → (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoate (1643771-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 40 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: hydrogen; 10 wt% Pd(OH)2 on carbon / water; ethanol / 20 °C

3.1: diisopropyl-carbodiimide / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With 10 wt% Pd(OH)2 on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; water; acetonitrile;

DOI:10.1002/chem.201402818

upstream raw materials:

3-(benzyloxy)-2,2-dimethyl-1-(2-phenylacetyl)imidazolidin-4-one

3-hydroxy-2,2-dimethyl-1-(2-phenylacetyl)imidazolidin-4-one

Nα-phthaloyl-L-phenylalanine

phenylacetyl chloride

Downstream raw materials:

(3R)-3-benzylmorpholine

2-((2S)-1-((3R)-3-benzylmorpholino)-1-oxo-3-phenylpropan-2-yl)isoindoline-1,3-dione

2-((2S)-1-((3S)-3-benzylmorpholino)-1-oxo-3-phenylpropan-2-yl)isoindoline-1,3-dione

(3S)-3-benzylmorpholine