N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

Base Information

Chemical Name:N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide
CAS No.:1074762-67-6
Molecular Formula:C₂₈H₂₉F₃N₂O₂
Molecular Weight:482.546
Hs Code.:

Synonyms:N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

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Chemical Property of N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

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Technology Process of N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

There total 7 articles about N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-8-{[benzyl(methyl)amino]methyl}-5-methyl-1,2,3,4-tetrahydronaphthalen-2-amine

: 36823-88-8
4-(trifluoromethoxy)benzoyl chloride

: 1074762-67-6
N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333 - 0.5h;

Reference yield:

: 1074763-45-3
(2R)-N-benzyl-8-bromo-5-methyl-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydronaphthalen-2-amine

: 1074762-67-6
N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 22 h / 70 °C

2.1: trimethylaluminum / toluene / 0.03 h / 20 °C

2.2: 60 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.08 h / 110 °C / Microwave irradiation

4.1: borane-THF / tetrahydrofuran / 2.5 h

4.2: 50 °C

5.1: triethylamine / dichloromethane / 0.08 - 0.5 h / 20 °C

With borane-THF; trimethylaluminum; ammonium formate; triethylamine; palladium diacetate; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1074763-46-4
methyl (7R)-7-{benzyl[(1S)-1-phenylethyl]amino}-4-methyl-5,6,7,8-tetrahydronaphthalene-1-carboxylate

: 1074762-67-6
N-[(2R)-8-([benzyl-(methyl)amino]methyl)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylaluminum / toluene / 0.03 h / 20 °C

1.2: 60 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.08 h / 110 °C / Microwave irradiation

3.1: borane-THF / tetrahydrofuran / 2.5 h

3.2: 50 °C

4.1: triethylamine / dichloromethane / 0.08 - 0.5 h / 20 °C

With borane-THF; trimethylaluminum; ammonium formate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene;