((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Base Information

Chemical Name:((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine
CAS No.:951155-03-6
Molecular Formula:C₁₉H₂₂BrN
Molecular Weight:344.294
Hs Code.:

Synonyms:((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Suppliers and Price of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

There total 6 articles about ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

: 1394290-38-0
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

: 951155-03-6
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Guidance literature:: With sodium hydroxide; In water; toluene; at 60 ℃;
DOI:10.1021/acs.oprd.5b00349

Reference yield:

: C₁₉H₂₀BrN

: 951155-03-6
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

: 1381802-56-7
((S)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Guidance literature:: With sodium tetrahydroborate; In methanol; isopropyl alcohol; at 0 ℃; for 1h; optical yield given as %de;
DOI:10.1021/jo300277y

Reference yield:

: 621-36-3
m-methylphenylacetic acid

: 951155-03-6
((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

: 1381802-56-7
((S)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; potassium carbonate / water

2: thionyl chloride / dichloromethane / 30 °C / Reflux

3: aluminum (III) chloride

4: toluene-4-sulfonic acid / toluene / 1 h / 50 °C

5: sodium tetrahydroborate / methanol; isopropyl alcohol / 1 h / 0 °C

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; bromine; potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane; water; isopropyl alcohol; toluene; 3: Friedel Crafts alkylation;
DOI:10.1021/jo300277y