N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Base Information

Chemical Name:N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine
CAS No.:115913-76-3
Molecular Formula:C₂₀H₂₁N₉O₄
Molecular Weight:451.445
Hs Code.:

N<sup>2</sup>-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Synonyms:N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Chemical Property:

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Technology Process of N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

There total 11 articles about N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 115913-75-2
9-(5-O-benzoyl-2-deoxy-β-D-threo-pentofuranosyl)guanine

: 115913-77-4
5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

: 115913-76-3
N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Guidance literature:: With lithium azide; triphenylphosphine; In various solvent(s); for 24h; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jm00118a033

Reference yield:

: 93-97-0
benzoic acid anhydride

: 115913-76-3
N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / Et₃N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h

2: LiN₃, Ph₃P / various solvent(s) / 24 h / Ambient temperature

With dmap; lithium azide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00118a033

Reference yield:

: 118-00-3
G

: 115913-76-3
N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine

Guidance literature:: Multi-step reaction with 5 steps

2: NH₃ / methanol / Ambient temperature

3: 93 percent / lithium triethylborohydride / tetrahydrofuran; dimethylsulfoxide / Ambient temperature

4: 61 percent / Et₃N, 4-dimethylaminopyridine / dimethylformamide / RT, 5 h; 4 deg C, 60 h

5: LiN₃, Ph₃P / various solvent(s) / 24 h / Ambient temperature

With dmap; lithium azide; ammonia; lithium triethylborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00118a033