N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

Base Information

Chemical Name:N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide
CAS No.:296766-66-0
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

Synonyms:N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

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Chemical Property of N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

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Technology Process of N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

There total 3 articles about N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 296766-73-9,1245643-19-9,408534-01-0
(1S)-N-[3-hydroxy-1-(hydroxymethyl)propyl]benzamide

: 296766-50-2
[(2S,4R,5R)-N-2-(2,2-dimethoxyethyl)-4-methyl-1,3-dioxan-5-yl]benzamide

: 296766-66-0
N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

Guidance literature:: With pyridinium p-toluenesulfonate; In chloroform; at 50 ℃; for 12h;
DOI:10.1002/1099-0690(200007)2000:14<2669::aid-ejoc2669>3.3.co;2-q

Reference yield:

: 1245643-19-9,408534-01-0
(1S)-N-[3-hydroxy-1-(hydroxymethyl)propyl]benzamide

: 398118-87-1
(2S,4R,5R)-N-(2-formylmethyl-4-methyl-1,3-dioxane-5-yl)benzamide

: 296766-66-0
N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

Guidance literature:: With magnesium chloride; In chloroform; at 20 ℃;
DOI:10.1021/jo0057351

Reference yield:

: 296766-50-2
[(2S,4R,5R)-N-2-(2,2-dimethoxyethyl)-4-methyl-1,3-dioxan-5-yl]benzamide

: 296766-66-0
N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalic acid; silicagel / CHCl₃ / 50 °C

2: MgCl₂ / CHCl₃ / 20 °C

With oxalic acid; silica gel; magnesium chloride; In chloroform;
DOI:10.1021/jo0057351