296766-50-2

Upstream product

• 102-52-3 malonaldehydebis(dimethylacetal) 
• 296766-71-7 (1S,2R)-N-[2-hydroxy-1-(hydroxymethyl)propyl]benzamide 
• 879559-64-5 N-[(2S,4R,5R)-2-(2,2-Dimethoxy-ethyl)-4-methyl-[1,3]dioxan-5-yl]-2,2,2-trifluoro-acetamide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 398118-91-7 methyl (1R,3S,2'S,4'R,5'R)-1-(5'-benzoylamino-4'-methyl-1',3'-dioxane-2'-yl)-methyl-1,2,3,4-tetrahydrocarboline-3-carboxylate 
• 398118-92-8 methyl (1S,3S,2'S,4'R,5'R)-1-(5'-benzoylamino-4'-methyl-1',3'-dioxane-2'-yl)-methyl-1,2,3,4-tetrahydrocarboline-3-carboxylate 
• 398118-93-9 (1R,2'S,4'R,5'R)-1-(5'-benzoylamino-4'-methyl-1',3'-dioxan-2'-yl)methyl-6-methoxy-1,2,3,4-tetrahydrocarboline-3-carboline 
• 398118-94-0 (1R,2'S,4'R,5'R)-1-(5'-benzoylamino-4'-methyl-1',3'-dioxane-2'-yl)methyl-1,2,3,4-tetrahydrocarboline-3-carboline 
• 296766-60-4 N,N'-methylenebis[(2S,4R,5R)/(2S,4S,5S)-4-methyl-1,3-dioxan-2,5-diyl]bisbenzamide 
• 296766-66-0 N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl]-[(2'S,5'R)-1,3-dioxacyclooctan-2,5-diyl]bisbenzamide 
• 296766-64-8 N,N'-methylene[(2S,4R,5R)-4-methyl-1,3-dioxan-2,5-diyl][(trans)-1,3-dioxan-2,5-diyl]bisbenzamide 
• 398118-87-1 (2S,4R,5R)-N-(2-formylmethyl-4-methyl-1,3-dioxane-5-yl)benzamide 

Relevant academic research and scientific papers

Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes

A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships.

Stereoselective transacetalization of 1,1,3,3-tetramethoxypropane and N- benzoylaminodiols

The transacetalization of 1,1,3,3-tetramethoxypropane and an N- benzoylaminodiol provided stereoselectively the corresponding 2,5- disubstituted-1,3-dioxanes. The stereochemistry of the rings formed in the transacetalization depended on the structure of the amino diol, and the ratio of the products depended on the reaction conditions, as expected. This kind of stereoselective transacetalization not only gives a series of useful building blocks but also generates interesting 1,3-dioxanes which target protein kinase C.