(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

Base Information

Chemical Name:(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile
CAS No.:1334037-52-3
Molecular Formula:C₂₆H₂₆N₂OS
Molecular Weight:414.571
Hs Code.:

Synonyms:(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

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Chemical Property of (2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

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Technology Process of (2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

There total 5 articles about (2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

: 1334037-51-2
(E)-3-[4-(hexyl-phenyl-amino)-phenyl]-2-thiophen-2-yl-acrylonitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1334037-52-3
(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

Guidance literature:: (E)-3-[4-(hexyl-phenyl-amino)-phenyl]-2-thiophen-2-yl-acrylonitrile; N,N-dimethyl-formamide; With trichlorophosphate; In 1,2-dichloro-ethane; at 0 - 90 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In 1,2-dichloro-ethane; Inert atmosphere;
DOI:10.1021/jo201057b

Reference yield:

: 1334037-50-1
4-[hexyl(phenyl)amino]benzaldehyde

: 1334037-52-3
(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

2.2: Inert atmosphere

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: Knoevenagel condensation / 2.1: Vilsmeier formylation;
DOI:10.1021/jo201057b

Reference yield:

: 111-25-1
1-bromo-hexane

: 1334037-52-3
(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 85 °C / Inert atmosphere

2.1: trichlorophosphate / 1,2-dichloro-ethane / 5 h / 0 - 90 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

4.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

4.2: Inert atmosphere

With potassium tert-butylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; 1,2-dichloro-ethane; 2.1: Vilsmeier formylation / 3.1: Knoevenagel condensation / 4.1: Vilsmeier formylation;
DOI:10.1021/jo201057b