(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

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Chemical Name:(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid
CAS No.:1334037-53-4
Molecular Formula:C₂₉H₂₇N₃O₂S
Molecular Weight:481.618
Hs Code.:

Synonyms:(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

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Chemical Property of (2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

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Technology Process of (2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

There total 6 articles about (2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

: 1334037-52-3
(2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile

: 372-09-8
cyanoacetic acid

: 1334037-53-4
(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: (2E)-2-(5-formylthiophen-2-yl)-3-{4-[hexyl(phenyl)amino]phenyl}prop-2-enenitrile; cyanoacetic acid; With piperidine; In chloroform; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In dichloromethane; chloroform; water; Inert atmosphere;
DOI:10.1021/jo201057b

Reference yield:

: 1334037-50-1
4-[hexyl(phenyl)amino]benzaldehyde

: 1334037-53-4
(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

2.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: piperidine / chloroform / 2 h / Inert atmosphere; Reflux

3.2: Inert atmosphere

With piperidine; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; 1.1: Knoevenagel condensation / 2.1: Vilsmeier formylation / 3.1: Knoevenagel condensation;
DOI:10.1021/jo201057b

Reference yield:

: 1334037-51-2
(E)-3-[4-(hexyl-phenyl-amino)-phenyl]-2-thiophen-2-yl-acrylonitrile

: 1334037-53-4
(2E)-2-cyano-3-{5-[(1E)-1-cyano-2-{4-[hexyl(phenyl)amino]phenyl}eth-1-en-1-yl]thiophen-2-yl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / 0 - 90 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: piperidine / chloroform / 2 h / Inert atmosphere; Reflux

2.2: Inert atmosphere

With piperidine; trichlorophosphate; In chloroform; 1,2-dichloro-ethane; 1.1: Vilsmeier formylation / 2.1: Knoevenagel condensation;
DOI:10.1021/jo201057b