1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione

Base Information

• Chemical Name: 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione
• CAS No.: 876760-61-1
• Molecular Formula: C₂₃H₂₄N₂O₅S₂
• Molecular Weight: 472.586

Synonyms:1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione

Chemical Property of 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione

There total 5 articles about 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,7R)-10,10-Dimethyl-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.01,5]dec-4-en-2-one (876760-57-5) → 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.01,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione (876760-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / AcOH; NaBH₃CN / 0.5 h / 20 °C

2: CH₂Cl₂ / 0.25 h

With sodium cyanoborohydride; acetic acid; In dichloromethane;

DOI:10.1016/j.tet.2005.10.042

Reference yield:

2-(2-tosylhydrazono)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid (876760-56-4) → 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.01,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione (876760-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / thionyl chloride / ethyl acetate / 4 h / Heating

2: 75 percent / AcOH; NaBH₃CN / 0.5 h / 20 °C

3: CH₂Cl₂ / 0.25 h

With thionyl chloride; sodium cyanoborohydride; acetic acid; In dichloromethane; ethyl acetate;

DOI:10.1016/j.tet.2005.10.042

Reference yield:

(1S)-(+)-ketopinic acid (464-78-8,6994-94-1,64234-14-6,40724-67-2) → 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.01,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione (876760-61-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / CH₂Cl₂ / 4 h / 20 °C

2: 90 percent / thionyl chloride / ethyl acetate / 4 h / Heating

3: 75 percent / AcOH; NaBH₃CN / 0.5 h / 20 °C

4: CH₂Cl₂ / 0.25 h

With thionyl chloride; sodium cyanoborohydride; acetic acid; In dichloromethane; ethyl acetate;

DOI:10.1016/j.tet.2005.10.042

upstream raw materials:

(1S,5R,7R)-10,10-Dimethyl-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]decan-2-one

oxo-thiophen-2-yl-acetyl chloride

(1S,7R)-10,10-Dimethyl-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-en-2-one

2-(2-tosylhydrazono)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 876760-61-1 1-[(1S,5R,7R)-10,10-Dimethyl-2-oxo-3-(toluene-4-sulfonyl)-3,4-diaza-tricyclo[5.2.1.0^1,5]dec-4-yl]-2-thiophen-2-yl-ethane-1,2-dione

Send

Send

Metric Ton KG G Pound L ML

Send

Send