2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

Base Information

Chemical Name:2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate
CAS No.:75971-24-3
Molecular Formula:C₂₉H₃₁FN₄O₃
Molecular Weight:502.589
Hs Code.:

Synonyms:2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

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Chemical Property of 2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

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Technology Process of 2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

There total 5 articles about 2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 73735-86-1
4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineethanol monohydrobromide

: 75971-24-3
2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 75971-24-3
2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 1.) ammonia / 1.) methanol, 2.) methanol, RT, overnight

4: triethylamine / CH₂Cl₂ / 24 h / 25 °C

With ammonia; hydrogen bromide; sodium carbonate; triethylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 75971-24-3
2-<4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinyl>ethyl 4-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 1.) ammonia / 1.) methanol, 2.) methanol, RT, overnight

3: triethylamine / CH₂Cl₂ / 24 h / 25 °C

With ammonia; hydrogen bromide; triethylamine; In dichloromethane;
DOI:10.1021/jm00150a029