N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine

Base Information

• Chemical Name: N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine
• CAS No.: 944503-14-4
• Molecular Formula: C₃₄H₂₉N₅OS
• Molecular Weight: 555.703

Synonyms:N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine

Chemical Property of N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine

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Technology Process of N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine

There total 9 articles about N₁-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-benzyloxy-phenylsulfanyl)-N3-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine (944503-18-8) + benzaldehyde (100-52-7) → N1-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N3-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine (944503-14-4)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 18h;

Reference yield:

2-chloro-6-methylnicotinonitrile (28900-10-9) → N1-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N3-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine (944503-14-4)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonia / ethanol / 20 h / 130 °C

2: toluene / 6 h / Heating / reflux

3: acetic acid / 0.33 h / 130 °C

4: iron; ammonium chloride / tetrahydrofuran; methanol; water / 1.5 h / Heating / reflux

5: sodium cyanoborohydride; acetic acid / methanol / 18 h / 20 °C

With ammonia; iron; sodium cyanoborohydride; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; water; acetic acid; toluene;

Reference yield:

2-amino-6-methylpyridine-3-carbonitrile (84647-20-1) → N1-benzyl-4-(4-benzyloxy-phenylsulfanyl)-N3-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine (944503-14-4)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 6 h / Heating / reflux

2: acetic acid / 0.33 h / 130 °C

3: iron; ammonium chloride / tetrahydrofuran; methanol; water / 1.5 h / Heating / reflux

4: sodium cyanoborohydride; acetic acid / methanol / 18 h / 20 °C

With iron; sodium cyanoborohydride; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; water; acetic acid; toluene;

upstream raw materials:

4-(4-benzyloxy-phenylsulfanyl)-N₃-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-benzene-1,3-diamine

benzaldehyde

2-amino-6-methylpyridine-3-carbonitrile

2-chloro-6-methylnicotinonitrile

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