2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide

Base Information

• Chemical Name: 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide
• CAS No.: 1431772-18-7
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.228
• Mol file: 1431772-18-7.mol

Synonyms:2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide

Chemical Property of 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide

There total 4 articles about 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

vinyl acetate (108-05-4,9003-20-7) + 2-(4-methylphenyl)-1,2,3-triazole N-oxide (1431772-07-4) → (E)-4-(2-p-tolyl-2H-1,2,3-triazol-4-yl)but-3-en-2-one N-oxide (1431772-17-6) + 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide (1431772-18-7)

Guidance literature:

With pyridine; palladium diacetate; silver carbonate; In 1,4-dioxane; tert-butyl alcohol; at 125 ℃; for 8h; Sealed tube; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol401002w

Reference yield:

N-4-methylphenylhydrazine (539-44-6) → 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide (1431772-18-7)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; water / 1 h / 20 °C / Inert atmosphere; Schlenk technique

2: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique

3: copper(II) sulfate / water; pyridine / 2 h / Reflux; Inert atmosphere; Schlenk technique

4: palladium diacetate; silver carbonate; pyridine / tert-butyl alcohol; 1,4-dioxane / 8 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

With pyridine; hydroxylamine hydrochloride; palladium diacetate; copper(II) sulfate; silver carbonate; sodium hydroxide; In 1,4-dioxane; pyridine; ethanol; water; acetic acid; tert-butyl alcohol;

DOI:10.1021/ol401002w

Reference yield:

2-(2-(p-tolyl)hydrazono)acetaldehyde (75815-82-6) → 2-p-tolyl-4-vinyl-2H-1,2,3-triazol N-oxide (1431772-18-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique

2: copper(II) sulfate / water; pyridine / 2 h / Reflux; Inert atmosphere; Schlenk technique

3: palladium diacetate; silver carbonate; pyridine / tert-butyl alcohol; 1,4-dioxane / 8 h / 125 °C / Sealed tube; Schlenk technique; Inert atmosphere

With pyridine; hydroxylamine hydrochloride; palladium diacetate; copper(II) sulfate; silver carbonate; sodium hydroxide; In 1,4-dioxane; pyridine; ethanol; water; tert-butyl alcohol;

DOI:10.1021/ol401002w

upstream raw materials:

vinyl acetate

2-(4-methylphenyl)-1,2,3-triazole N-oxide

N-4-methylphenylhydrazine

2-(2-(p-tolyl)hydrazono)acetaldehyde