539-44-6

Basic information

• Product Name: p-tolyl-hydrazin
• Synonyms: (4-methylphenyl)-hydrazin;4-Tolylhydrazine;p-tolyl-hydrazin
• CAS NO: 539-44-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.1677
• EINECS: 208-717-2
• Mol File: 539-44-6.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 242.8 °C at 760 mmHg
• Flash Point: 115.3 °C
• Appearance: /
• Density: 1.087 g/cm³
• Vapor Pressure: 0.0333mmHg at 25°C
• CAS DataBase Reference: p-tolyl-hydrazin(CAS DataBase Reference)
• NIST Chemistry Reference: p-tolyl-hydrazin(539-44-6)
• EPA Substance Registry System: p-tolyl-hydrazin(539-44-6)

Safety Data

• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 539-44-6(Hazardous Substances Data)

Usage

Description

P-tolyl-hydrazine, with the chemical formula C7H10N2, is a colorless to pale yellow liquid characterized by a strong odor. It is highly flammable and recognized as a hazardous substance due to its potential to cause skin and eye irritation upon contact, as well as respiratory and nervous system effects with prolonged exposure. Careful handling and storage are essential to mitigate health and safety risks.

Uses

Used in Pharmaceutical Synthesis:
P-tolyl-hydrazine is utilized as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
p-tolyl-hydrazin serves as a crucial component in the production of agrochemicals, playing a significant role in the creation of pesticides and other agricultural products to protect crops and enhance yields.
Used in Dye and Pigment Manufacturing:
P-tolyl-hydrazine is employed as a raw material in the manufacture of dyes and pigments, contributing to the coloration and quality of various products in different industries.
Used in Organic Compound Synthesis:
Beyond its applications in pharmaceuticals, agrochemicals, dyes, and pigments, p-tolyl-hydrazine is also used in the synthesis of other organic compounds, highlighting its versatility in the chemical industry.

InChI:InChI=1/C7H10N2.ClH/c1-6-2-4-7(9-8)5-3-6;/h2-5,9H,8H2,1H3;1H

Upstream product

• 2028-84-4 p-methylbenzenediazonium chloride 
• 64-17-5 ethanol 
• 622-74-2 N-phenyl-N'-p-tolyl-triazene 
• 39479-55-5 sulfinyl-p-tolyl-hydrazine 
• 21988-82-9 4-oxo-3-p-tolyl-4,5-dihydro-[1,2,3]thiadiazolium betaine 
• 100-46-9 benzylamine 
• 106-43-4 para-chlorotoluene 
• 35467-65-3 4-methylphenylhydrazine hydrochloride 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 7647-01-0 hydrogenchloride 
• 53464-34-9 p-CH₃C₆H₄NNN(C₂H₅)C₆H₅ 
• 7664-93-9 sulfuric acid 

Downstream Products

• 61700-79-6 N'-(4-methylphenyl)acetohydrazide 
• 860253-09-4 N-p-tolyl-N'-trityl-hydrazine 
• 38577-24-1 formic acid-(N'-p-tolyl-hydrazide) 
• 89314-29-4 2-p-tolylhydrazono-propionic acid 
• 7515-90-4 4-p-tolylhydrazono-valeric acid 
• 21364-09-0 diphenyl-acetic acid-(N'-p-tolyl-hydrazide) 
• 3352-86-1 1-p-tolylpyrazolidin-3-one 
• 66390-72-5 isobutyric acid-(N'-p-tolyl-hydrazide) 
• 80957-51-3 butane-2,3-dione oxime p-tolylhydrazone 
• 100-65-2 N-Phenylhydroxylamine 
• 5756-83-2 1-(4-methylphenyl)-3-phenyl-3-hydroxytriazene 
• 25112-07-6 Cyanacetaldehyd-p-tolylhydrazon 
• 109002-25-7 quinoxaline-2-carboxaldehyde p-tolylhydrazone 
• 95526-15-1 N-[1-Phenyl-1-pyridin-2-yl-meth-(Z)-ylidene]-N'-p-tolyl-hydrazine 

Relevant articles and documents

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

1, 3, 4-oxadiazole hydrazide compound as well as preparation method and application thereof

The invention relates to a 1, 3, 4-oxadiazole hydrazide compound as well as a preparation method and application thereof. The compound has a structure as shown in a general formula (I), according to the invention, the method includes taking a 1, 3, 4-oxadiazole compound as a basis and introducing hydrazide into the system; the compound has a good inhibition effect on plant pathogenic bacteria, fungi and oomycetes, and has a good inhibition effect on pathogenic bacteria such as rice bacterial leaf blight, wheat scab, pepper fusarium wilt, sclerotinia sclerotiorum, colletotrichum gloeosporioides, phytophthora infestans, blueberry root rot and the like.

Lewis Acid Catalyzed Annulation of Cyclopropane Carbaldehydes and Aryl Hydrazines: Construction of Tetrahydropyridazines and Application Toward a One-Pot Synthesis of Hexahydropyrrolo[1,2- b]pyridazines

In this report, a facile synthesis of tetrahydropyridazines via a Lewis acid catalyzed annulation reaction of cyclopropane carbaldehydes and aryl hydrazines has been demonstrated. Moreover, the generated tetrahydropyridazine further participated in a cycloaddition reaction with donor-acceptor cyclopropanes to furnish hexahydropyrrolo[1,2-b]pyridazines. We also performed these two steps in one pot in a consecutive manner. In addition, a monodecarboxylation reaction of hexahydropyrrolo[1,2-b]pyridazine was achieved with a good yield.