ethane-1,2-diylbis(phenylphosphinic acid)

Base Information

• Chemical Name: ethane-1,2-diylbis(phenylphosphinic acid)
• CAS No.: 1089-77-6
• Molecular Formula: C14H16 O4 P2
• Molecular Weight: 310.226
• Mol file: 1089-77-6.mol

Synonyms:Phosphinic acid, 1,2-ethanediylbis[phenyl- (9CI); Phosphinic acid, ethylenebis[phenyl-(6CI,7CI,8CI); 1,2-Ethanediylbis(phenylphosphinicacid); NSC 407882

Chemical Property of ethane-1,2-diylbis(phenylphosphinic acid)

Chemical Property:

• Vapor Pressure: 4.1E-19mmHg at 25°C
• Boiling Point: 674.5°C at 760 mmHg
• Flash Point: 361.7°C
• PSA: 94.22000
• Density: 1.34g/cm³
• LogP: 2.17820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

P,P''-DiphenylethylenediphosphinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: P,P''-Diphenylethylenediphosphinic Acid can bind to ΔF508-CFTR-NBD1 and act as protein-protein interaction inhibitor.

Technology Process of ethane-1,2-diylbis(phenylphosphinic acid)

There total 7 articles about ethane-1,2-diylbis(phenylphosphinic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dichlorophenylphosphine (644-97-3) → P,P′-diphenylethylenediphosphinic acid (1089-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: MeOH / pyridine; hexane

2: (i) (heating), (ii) aq. NaOH

With methanol; In pyridine; hexane;

DOI:10.1021/ja01487a043

Reference yield:

1,2-bis[isopropoxy(phenyl)phosphoryl]ethane (2240-53-1) → P,P′-diphenylethylenediphosphinic acid (1089-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: aq. Na₂O₂

With lithium aluminium tetrahydride; sodium peroxide; In diethyl ether;

Reference yield:

phenylphosphonous acid dimethyl ester (2946-61-4) + cis+trans-dibromoethylene (540-49-8) → methylphenylphosphinic acid (4271-13-0) + P,P′-diphenylethylenediphosphinic acid (1089-77-6)

Guidance literature:

Multistep reaction; (i) (heating), (ii) aq. NaOH;

DOI:10.1021/ja01487a043

upstream raw materials:

P,P'-diphenyl-P,P'-ethanediyl-bis-phosphinic acid diethyl ester

phenylphosphonous acid dimethyl ester

cis+trans-dibromoethylene

1,2-Bis(phenylphosphino)ethane