3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide

Base Information

• Chemical Name: 3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide
• CAS No.: 941576-68-7
• Molecular Formula: C₁₂H₁₃Cl₃O₅S
• Molecular Weight: 375.657
• Mol file: 941576-68-7.mol

Synonyms:3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide

Chemical Property of 3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide

There total 1 articles about 3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4′-methoxyphenoxy)propane-1-sulfonyl chloride (118943-25-2) + chloral (75-87-6) → 3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide (941576-68-7)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; 1,2,2,6,6-pentamethylpiperidine; In dichloromethane; at -15 ℃; for 2.75h;

DOI:10.1002/anie.200604796

Reference yield: 99.0%

3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide (941576-68-7) → (3R)-1,1-dichloro-5-(4-methoxyphenoxy)-pent-1-ene-3-sulfonic acid (1067639-09-1)

Guidance literature:

With 10% Pd/C; hydrogen; In ethanol; for 21h; under 760.051 Torr; optical yield given as %ee; chemoselective reaction;

DOI:10.1055/s-2008-1078417

Reference yield:

3-(2-(4-methoxyphenoxy)ethyl)-4-trichloromethyl-1-oxa-2-thiacyclobutan-2,2-dioxide (941576-68-7) → C13H16Cl2O5S

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 21 h / 760.05 Torr

2: methanol / 0.5 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In methanol; ethanol;

DOI:10.1002/chem.201003542

upstream raw materials:

3-(4′-methoxyphenoxy)propane-1-sulfonyl chloride

chloral

Downstream raw materials:

(3R)-1,1-dichloro-5-(4-methoxyphenoxy)-pent-1-ene-3-sulfonic acid