10.1007/BF00815925
The research aimed to further explore the structure-activity relationships of the antifungal lead compound α-trichloromethyl-3-pyridinemethanol (1a) by synthesizing and evaluating its derivatives, including esters, (thio-)carbamates, and sulfonates. The study involved the optical resolution and N-oxidation of 1a, providing insights into the effects of structural variations on antifungal activity. Key chemicals used in the synthesis process included 3-Pyridyllithium, Chloral, Isocyanates, Car-Bamoylchlorides, Triethylamin, and various other reagents for the preparation of different derivatives. The conclusions drawn from the research detailed the successful synthesis and characterization of the derivatives, as well as their antifungal properties, thereby expanding the understanding of the lead structure's potential as a fungicide.
10.1007/BF00952933
The research investigates the interaction of 2-diethoxyphosphoryl-1,3,2-dithiaphosphorinane (I) with chloral in the presence of water. The purpose of the study is to understand the chemical reactions and products formed under these conditions. The researchers found that in the presence of water, the initial hydrolysis of compound (I) leads to the formation of a cyclic phosphite (II), which then reacts with chloral to produce 2-hydroxy-(2,2,2-trichloro-1-hydroxyethyl)-1,3,2-dithiaphosphorinane (III) in an 86% yield. The study concludes that the reaction proceeds without secondary conversions when chloral is present, indicating the significant role of chloral in stabilizing the reaction products.
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