(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine

Base Information

• Chemical Name: (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine
• CAS No.: 1257229-81-4
• Molecular Formula: C₁₄H₁₅F₄N₅O₂S
• Molecular Weight: 393.365
• Mol file: 1257229-81-4.mol

Synonyms:(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine

Chemical Property of (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine

Chemical Property:

Purity/Quality:

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Technology Process of (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine

There total 1 articles about (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.3%

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine (946399-84-4,1414960-67-0) + 1H-1,2,4-triazole-5-sulfonyl chloride (6461-29-6) → (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine (1257229-81-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 72.4%

(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine (1257229-81-4) + methyl iodide (74-88-4) → (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-[(1-methyl-1H-1,2,4-triazol-5-yl)sulfonyl]piperazine

Guidance literature:

(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-(1H-1,2,4-triazol-5-ylsulfonyl)piperazine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 6h; Reflux;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 1h; Reflux;

upstream raw materials:

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

1H-1,2,4-triazole-5-sulfonyl chloride