Technology Process of N-(2-chloro-4-nitrophenyl)-4-hydroxy-[1,1‘-biphenyl]-3-carboxamide
There total 3 articles about N-(2-chloro-4-nitrophenyl)-4-hydroxy-[1,1‘-biphenyl]-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; potassium carbonate;
In
water; N,N-dimethyl-formamide;
at 20 - 55 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2013.01.101
- Guidance literature:
-
Multi-step reaction with 2 steps
1: phosphorus tribromide / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Inert atmosphere
2: palladium diacetate; potassium carbonate / N,N-dimethyl-formamide; water / 2 h / 20 - 55 °C / Inert atmosphere
With
palladium diacetate; phosphorus tribromide; potassium carbonate;
In
5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide;
1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.01.101
- Guidance literature:
-
With
phosphorus trichloride;
In
5,5-dimethyl-1,3-cyclohexadiene;
for 1h;
Reflux;
Inert atmosphere;
