119-30-2

Usage

Chemical Properties

white to slightly beige powder

Uses

2-hydroxy-5-iodobenzoic acid is a reagent in various organic chemical reactions leading to pharmaceutical compounds. It is involved in the synthesis of labeled benzamide analogs for tumor imaging as well as the synthesis of the dye, Congo Red, for biological analyses.

Purification Methods

Crystallise the acid from water. [Beilstein 10 H 112.]

InChI:InChI=1/C7H5IO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)/p-1

Upstream product

• 89-57-6 5-Aminosalicylic Acid 
• 4068-75-1 methyl 5-iodosalicylate 
• 68596-89-4 3-carboxylato-4-hydroxybenzenediazonium 
• 69-72-7 salicylic acid 
• 14192-12-2 2,5-diiodobenzoic acid 
• 64-17-5 ethanol 
• 7553-56-2 iodine 
• 10034-85-2 hydrogen iodide 
• 7732-18-5 water 
• 54-21-7 sodium salicylate 
• 119-36-8 methyl salicylate 

Downstream Products

• 15125-84-5 ethyl 2-hydroxy-5-iodobenzoate 
• 609-23-4 2,4,6-Triiodophenol 
• 22621-43-8 2-hydroxy-5-iodo-3-nitro-benzoic acid 
• 490-79-9 2,5-dihydroxybenzoic acid. 
• 133-91-5 3,5-diiodosalicylic acid 
• 1503-54-4 2-acetoxy-5-iodobenzoic acid 
• 4068-75-1 methyl 5-iodosalicylate 
• 90425-97-1 4',5-di-iodo-2'-methylsalicylanilide 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 77067-95-9 4'-bromo-5-iodo-2'-methylsalicylanilide 
• 77067-94-8 4'-chloro-5-iodo-2'-methylsalicylanilide 
• 102297-97-2 3-acetyl-2-hydroxy-5-iodobenzoic acid 
• 182616-52-0 5-Diphenylphosphanyl-2-hydroxy-benzoic acid 
• 69-72-7 salicylic acid 

Related news

The determination of the sodium salt of 5-Iodosalicylic acid (cas 119-30-2) and its metabolites in urine08/30/2019

A method for the determination of the sodium salt of 5-iodosalicyhc acid (5-I-S-Na) and total iodine is described. The method for the determination of 5-T-S-Na is based on the ultraviolet light absorption of this substance. Control experiments with the method for the determination of 5-1-S-Na an...detailed

The absorption of iodine from 5-Iodosalicylic acid (cas 119-30-2) by hydroponically grown lettuce08/28/2019

The aim of the study was to determine the effect of various doses of 5-iodosalicylic acid (5I-SA; organoiodine compound) on the growth, chemical composition, and efficiency of iodine biofortification of lettuce cultivated in a nutrient film technique hydroponic system. The additional purpose was...detailed

Relevant academic research and scientific papers

Iodination of aromatic compounds with iodine and n-butyltriphenylphosphonium peroxodisulfate

Iodine and n-butyltriphenylphosphonium peroxodisulfate can be successfully used for the iodination of some aromatic compounds in acetonitrile as solvent. The yields obtained are good to excellent.

Novel, water-based procedure for the mono iodination of aromatic amines and phenols

A mixture of potassium chlorate and potassium iodide was found to be a good iodinating agent for various aromatic amines and phenols with excellent yields in the presence of mineral acid in aqueous medium. Copyright Taylor & Francis Group, LLC.

NCBSI/KI: A Reagent System for Iodination of Aromatics through in Situ Generation of I-Cl

In situ iodine monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system has been developed. The NCBSI reagent requires no activation due to longer bond length, lower bond dissociation energy, and higher absolute charge density on nitrogen. The system is adequate for mono- and diiodination of a wide range of moderate to highly activated arenes with good yield and purity. Moreover, the precursor N-(benzenesulfonyl)benzenesulfonamide can be recovered and transformed to NCBSI, making the protocol eco-friendly and cost-effective.

Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogenous conditions, we were keen on developing iodination protocol of arenes that can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activates N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tunes sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chemicals, API, and natural products.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

HPK1 INHIBITORS, PREPARATION METHOD AND APPLICATION THEREOF

Disclosed are HPK-1 inhibitors having a structure represented by Formula (X), pharmaceutical compositions comprising the HPK-1 inhibitors, methods of using the HPK-1 inhibitors, such as treating cancers, methods of preparing the HPK-1 inhibitors, and the synthetic intermediates.

Method for the synthesis of many halo benzoic acid

The invention provides a poly-halogenated benzoic acid synthesizing method. The method comprises the following steps: dissolving substituted benzoic acid, halogen and organic strong acid in a polar solvent for increasing temperature, after oxidation at a temperature of 50-70 DEG C, performing heat preservation at the temperature of 60-80 DEG C for 2-6 h, adding a right amount of water, and cooling to a room temperature, so as to obtain poly-halogenated benzoic acid. According to the invention, synthetic reaction is performed in an alcohols solvent, the halogen simple substance is used as a halogenating reagent, a small amount of organic strong acid is added, used as a catalyst, and used for catalyzing the electrophilic substitution reaction of the halogen to benzene rings, and hydrogen peroxide is dropwise added during the reaction to enable the halogen simple substance in the reaction system to be oxidized into halide ions so as to improve the utilization rate of the halogen and achieve the effect of atom economy.

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds under Acid-Free Conditions

Isoquinolinium dichromate and isoquinolinium chlorochromate were found as efficient catalysts to trigger oxidative bromination and iodination of aromatic hydrocarbons with KBr/KI and KHSO4 under acid-free conditions. Reaction times reduced highly significantly under sonication, followed by corresponding mono bromo derivatives in very good yield with high regioselectivity.

Gold(I)-catalyzed iodination of arenes

A wide variety of electron-rich arenes were efficiently converted into the corresponding iodinated compounds via a gold(I)-catalyzed reaction under mild conditions. Georg Thieme Verlag Stuttgart. New York.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.