(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

Base Information

Chemical Name:(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid
CAS No.:1309777-89-6
Molecular Formula:C₂₇H₂₈F₂N₃O₅*Na
Molecular Weight:535.523
Hs Code.:

Synonyms:(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

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Chemical Property of (3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

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Technology Process of (3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

There total 8 articles about (3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310-73-2
sodium hydroxide

: 950741-95-4
(R,R)-7-[5-cyclopropyl-4-(3-fluoro-benzylcarbamoyl)-2-(4-fluoro-phenyl)-imidazol-1-yl]-3,5-dihydroxy-heptanoic acid

: 1309777-89-6
(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1319751-79-5
C₃₁H₃₇F₂N₃O₅

: 1309777-89-6
(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 2h;
DOI:10.1016/j.bmcl.2010.11.103

Reference yield:

: 1319747-57-3
C₂₆H₂₃NO₃

: 1309777-89-6
(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: toluene-4-sulfonic acid; acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 25 °C

4: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5: Acidic conditions

6: sodium hydroxide / tetrahydrofuran; water / 2 h / 50 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.11.103