3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester

Base Information

• Chemical Name: 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester
• CAS No.: 867308-95-0
• Molecular Formula: C₂₀H₁₈FNO₄
• Molecular Weight: 355.366

Synonyms:3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester

Chemical Property of 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester

Chemical Property:

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Technology Process of 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester

There total 5 articles about 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C13H15NO3 (934425-35-1) + 4-fluorobenzoyl chloride (403-43-0) → 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester (867308-95-0)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20 ℃; pH=8;

Reference yield:

C13H15NO3*ClH + 4-fluorobenzoyl chloride (403-43-0) → 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester (867308-95-0)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; pH=> 8;

Reference yield:

C26H23NO3 (1319747-57-3) + 4-fluorobenzoyl chloride (403-43-0) → 3-Cyclopropyl-2-(4-fluoro-benzoylamino)-3-oxo-propionic acid benzyl ester (867308-95-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2010.11.103

upstream raw materials:

C₁₃H₁₅NO₃

4-fluorobenzoyl chloride

C₂₆H₂₃NO₃

benzyl 2-(diphenylmethyleneamino)acetate

Downstream raw materials:

C₂₈H₃₁FN₃O₆^(1-)*Na⁽¹⁺⁾

C₂₈H₃₁FN₃O₆^(1-)*Na⁽¹⁺⁾

C₂₇H₂₈F₂N₃O₅^(1-)*Na⁽¹⁺⁾

(3R,5R)-7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid

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