8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Base Information

Chemical Name:8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
CAS No.:130884-76-3
Molecular Formula:C₂₂H₂₇ClN₂O₃S
Molecular Weight:434.987
Hs Code.:

Synonyms:8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Chemical Property of 8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Technology Process of 8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

There total 10 articles about 8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23474-98-8
2-amino-5-chlorobenzenethiol

: 130884-76-3
8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 60.5 percent / toluene / 24 h / 80 °C

2: 97.9 percent / 5percent aq. NaOH / ethanol / 3 h / Ambient temperature

3: 80.3 percent / xylene / 24 h / Heating

4: 80 percent / aq. K₂CO₃ / acetone / 17 h / Heating

5: 1.) NaH / 1.) toluene, DMSO, 30 deg C - 40 deg C, 30 min, 2.) toluene, DMSO, 50 deg C - 60 deg C, 4.5 h

With sodium hydroxide; sodium hydride; potassium carbonate; In ethanol; acetone; toluene; xylene;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 130884-76-3
8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 60.5 percent / toluene / 24 h / 80 °C

2: 97.9 percent / 5percent aq. NaOH / ethanol / 3 h / Ambient temperature

3: 80.3 percent / xylene / 24 h / Heating

4: 80 percent / aq. K₂CO₃ / acetone / 17 h / Heating

5: 1.) NaH / 1.) toluene, DMSO, 30 deg C - 40 deg C, 30 min, 2.) toluene, DMSO, 50 deg C - 60 deg C, 4.5 h

With sodium hydroxide; sodium hydride; potassium carbonate; In ethanol; acetone; toluene; xylene;
DOI:10.1021/jm00106a032

Reference yield:

: 14371-79-0
2-nitro-5-chlorothiophenol

: 130884-76-3
8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 71.5 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 82.4 percent / 10percent NaOH / methanol / 8 h / Ambient temperature

3: 78.8 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

4: 80.3 percent / xylene / 24 h / Heating

5: 80 percent / aq. K₂CO₃ / acetone / 17 h / Heating

6: 1.) NaH / 1.) toluene, DMSO, 30 deg C - 40 deg C, 30 min, 2.) toluene, DMSO, 50 deg C - 60 deg C, 4.5 h

With sodium hydroxide; zinc diacetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; ethanol; acetone; toluene; xylene;
DOI:10.1021/jm00106a032