2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Base Information

Chemical Name:2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
CAS No.:1259807-03-8
Molecular Formula:C₃₂H₄₅N₃O₇
Molecular Weight:583.725
Hs Code.:

2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Synonyms:2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

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Chemical Property of 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

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Technology Process of 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

There total 5 articles about 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095263-19-6
(1R,2S,3S,4S)-2-(L(-)-menthyl) 3-methyl 7-oxobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

: 1259807-03-8
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux; Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: chlorotriisopropylsilane; trifluoroacetic acid / 18 h / 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: ethanol / 2.5 h / Reflux; Inert atmosphere

4.1: tin(ll) chloride / ethanol / 2 h / Reflux; Inert atmosphere

4.2: Saturated solution

With chlorotriisopropylsilane; toluene-4-sulfonic acid; trifluoroacetic acid; tin(ll) chloride; In ethanol; toluene; 1.1: Ugi condensation / 1.2: Ugi condensation;
DOI:10.1021/ol102577q

Reference yield:

: 1259807-28-7
C₂₇H₃₅N₃O₇

: 1259807-03-8
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2.5 h / Reflux; Inert atmosphere

2.1: tin(ll) chloride / ethanol / 2 h / Reflux; Inert atmosphere

2.2: Saturated solution

With tin(ll) chloride; In ethanol;
DOI:10.1021/ol102577q

Reference yield:

: 1259807-01-6
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

: 1259807-03-8
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(tertbutoxycarbonylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chlorotriisopropylsilane; trifluoroacetic acid / 18 h / 20 °C / Inert atmosphere

1.2: Saturated solution

2.1: ethanol / 2.5 h / Reflux; Inert atmosphere

3.1: tin(ll) chloride / ethanol / 2 h / Reflux; Inert atmosphere

3.2: Saturated solution

With chlorotriisopropylsilane; trifluoroacetic acid; tin(ll) chloride; In ethanol;
DOI:10.1021/ol102577q