2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Base Information

Chemical Name:2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
CAS No.:1259807-01-6
Molecular Formula:C₃₆H₄₅N₃O₉
Molecular Weight:663.768
Hs Code.:

2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Synonyms:2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

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Chemical Property of 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

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Technology Process of 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

There total 1 articles about 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1095263-19-6
(1R,2S,3S,4S)-2-(L(-)-menthyl) 3-methyl 7-oxobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

: 20781-20-8
2,4-Dimethoxybenzylamine

: 74739-36-9
1-isocyano-2-nitrobenzene

: 1259807-01-6
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

Guidance literature:: (1R,2S,3S,4S)-2-(L(-)-menthyl) 3-methyl 7-oxobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate; 2,4-Dimethoxybenzylamine; With toluene-4-sulfonic acid; In toluene; for 3h; Reflux; Inert atmosphere;

1-isocyano-2-nitrobenzene; With trifluoroacetic acid; In methanol; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol102577q

Reference yield: 98.0%

: 1259807-01-6
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

: 1259807-28-7
C₂₇H₃₅N₃O₇

Guidance literature:: 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate; With chlorotriisopropylsilane; trifluoroacetic acid; at 20 ℃; for 18h; Inert atmosphere;

With sodium hydrogencarbonate; In water; Saturated solution;
DOI:10.1021/ol102577q

Reference yield:

: 1259807-01-6
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-methyl (1R,2S,3S,4S,7R)-7-(2,4-dimethoxybenzylamino)-7-(2-nitrophenylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate

: C₃₂H₄₃N₃O₉

Guidance literature:: Multi-step reaction with 2 steps

1.1: chlorotriisopropylsilane; trifluoroacetic acid / 18 h / 20 °C / Inert atmosphere

1.2: Saturated solution

2.1: ethanol / 2.5 h / Reflux; Inert atmosphere

With chlorotriisopropylsilane; trifluoroacetic acid; In ethanol;
DOI:10.1021/ol102577q