Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

Base Information

Chemical Name:Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate
CAS No.:1448441-72-2
Molecular Formula:C₂₇H₂₀F₂N₄O₃
Molecular Weight:486.478
Hs Code.:

Synonyms:Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

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Chemical Property of Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

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Technology Process of Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

There total 6 articles about Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1448441-71-1
Benzyl 5-(benzyloxy)-3,4-difluoro-2-((2-fluorophenyl)amino)benzoate

: 1448441-72-2
Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

Reference yield:

: 2822-41-5
2,3,4-trifluorophenol

: 1448441-72-2
Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetone / 24 h / 50 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

With n-butyllithium; sodium azide; sodium carbonate; potassium hydrogencarbonate; diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 100-39-0
benzyl bromide

: 1448441-72-2
Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetone / 24 h / 50 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

With n-butyllithium; sodium azide; sodium carbonate; potassium hydrogencarbonate; diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;