tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate
CAS No.:1425970-96-2
Molecular Formula:C₂₈H₄₄N₂O₄Si
Molecular Weight:500.754
Hs Code.:

Synonyms:tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425970-71-3
tert-butyl 4-(4-(bromomethyl)benzylidene)piperidine-1-carboxylate

: 131653-51-5
(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one

: 1425970-96-2
tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

Guidance literature:: (4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.16667h;

tert-butyl 4-(4-(bromomethyl)benzylidene)piperidine-1-carboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 1425970-70-2
tert-butyl 4-(4-(hydroxymethyl)benzylidene)piperidine-1-carboxylate

: 1425970-96-2
tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1.17 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C / Cooling with ice

With carbon tetrabromide; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 726185-65-5
tert-butyl 4-[4-(ethoxycarbonyl)benzylidene]piperidine-1-carboxylate

: 1425970-96-2
tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 h / 20 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1.17 h / 0 - 20 °C

3.2: 3 h / 0 - 20 °C / Cooling with ice

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;