2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

Base Information

Chemical Name:2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide
CAS No.:84922-97-4
Molecular Formula:C₂₀H₂₄FN₅O₂
Molecular Weight:385.441
Hs Code.:

Synonyms:2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

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Chemical Property of 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

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Technology Process of 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

There total 6 articles about 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 76352-25-5
2-amino-4-methoxy-N-(8-azabicyclo<3,2,1>oct-3 β-yl)-5-pyrimidine carboxamide

: 456-42-8
m-fluorobenzyl chloride

: 84922-97-4
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

Guidance literature:: With potassium carbonate; In acetone; for 36h; Heating;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 84922-97-4
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

Guidance literature:: Multi-step reaction with 6 steps

2: NH₂OH*HCl / 0.67 h

3: 80 percent / Na / pentan-1-ol / 80 °C / Heating

4: 1.) NEt₃, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT

5: 93 percent / maleic acid, H₂ / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature

6: 94 percent / K₂CO₃ / acetone / 36 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium; chloroformic acid ethyl ester; potassium carbonate; triethylamine; maleic acid; palladium on activated charcoal; In ethanol; pentan-1-ol; acetone;

Reference yield:

: 532-24-1
tropinone

: 84922-97-4
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: NH₂OH*HCl / 0.67 h

2: 80 percent / Na / pentan-1-ol / 80 °C / Heating

3: 1.) NEt₃, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT

4: 93 percent / maleic acid, H₂ / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature

5: 94 percent / K₂CO₃ / acetone / 36 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium; chloroformic acid ethyl ester; potassium carbonate; triethylamine; maleic acid; palladium on activated charcoal; In ethanol; pentan-1-ol; acetone;