(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

Base Information

Chemical Name:(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one
CAS No.:142696-26-2
Molecular Formula:C₁₈H₁₆O₄
Molecular Weight:296.323
Hs Code.:

Synonyms:(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

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Chemical Property of (2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

Chemical Property:

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Technology Process of (2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

There total 11 articles about (2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142602-19-5
4-(N-benzamido)-(2S)-benzyl-6-(methoxycarbonyl)-2H-benzopyran

: 142696-26-2
(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

Guidance literature:: With hydrogenchloride; In methanol; at 50 ℃; for 2h;
DOI:10.1002/jhet.5570290223

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 142696-26-2
(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / 98percent H₂SO₄ / CH₂Cl₂ / 18 h / Heating

2: 70 percent / (C₆H₅)3P, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

3: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 30 h / Ambient temperature

4: 99 percent / triphenylphosphine dibromide / CH₂Cl₂ / 28 °C

5: methanesulfonic acid / 20 °C

6: Et₃N, Ac₂O / dimethylformamide / 1 h / 37 °C

7: 4 N HCl / acetone / Ambient temperature

8: 1 M sodium hypochlorite / ethyl acetate / 4 h / Ambient temperature

9: Zn, AcOH

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; methanesulfonic acid; di-isopropyl azodicarboxylate; sulfuric acid; acetic anhydride; acetic acid; triethylamine; triphenylphosphine; zinc; dibromotriphenylphosphorane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570290223

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 142696-26-2
(2S)-benzyl-6-(methoxycarbonyl)-2,3-dihydro-4H-benzopyran-4-one

Guidance literature:: Multi-step reaction with 10 steps

1: 51 percent / sodium nitrite, 1 M H₂SO₄ / H₂O / Ambient temperature

2: 94 percent / 98percent H₂SO₄ / CH₂Cl₂ / 18 h / Heating

3: 70 percent / (C₆H₅)3P, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

4: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 30 h / Ambient temperature

5: 99 percent / triphenylphosphine dibromide / CH₂Cl₂ / 28 °C

6: methanesulfonic acid / 20 °C

7: Et₃N, Ac₂O / dimethylformamide / 1 h / 37 °C

8: 4 N HCl / acetone / Ambient temperature

9: 1 M sodium hypochlorite / ethyl acetate / 4 h / Ambient temperature

10: Zn, AcOH

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; methanesulfonic acid; di-isopropyl azodicarboxylate; sulfuric acid; acetic anhydride; acetic acid; triethylamine; triphenylphosphine; zinc; sodium nitrite; dibromotriphenylphosphorane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570290223