2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2-(phenylmethyl)-, (R)-

Base Information

Chemical Name:2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2-(phenylmethyl)-, (R)-
CAS No.:109210-00-6
Molecular Formula:C17H16O2
Molecular Weight:252.313
Hs Code.:
Mol file:109210-00-6.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2-(phenylmethyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2-(phenylmethyl)-, (R)-

There total 21 articles about 2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2-(phenylmethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109210-11-9
(2R)-benzyl-6-(hydroxymethyl)-2,3-dihydro-4H-benzopyran

: 109210-00-6
(2R)-benzyl-6-(formyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: With manganese(IV) oxide; In toluene; for 2h;
DOI:10.1002/jhet.5570290223

Reference yield:

: 24698-77-9
ethyl Chroman-2-carboxylate

: 109210-00-6
(2R)-benzyl-6-(formyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / H₂O

2: 94 percent / NaBH₄ / tetrahydrofuran; H₂O / Ambient temperature

3: 94 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 85 percent / cuprous bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / 2.5 h / 0 °C

5: 1.) POCl₃ / 1.) 15 min, 2.) a.) CH₂Cl₂, RT, 15 min, b.) 65 deg C, 1 h

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1002/jhet.5570290223

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 109210-00-6
(2R)-benzyl-6-(formyl)-2,3-dihydro-4H-benzopyran

Guidance literature:: Multi-step reaction with 13 steps

1: 51 percent / sodium nitrite, 1 M H₂SO₄ / H₂O / Ambient temperature

2: 94 percent / 98percent H₂SO₄ / CH₂Cl₂ / 18 h / Heating

3: 70 percent / (C₆H₅)3P, diisopropyl azodicarboxylate / tetrahydrofuran / Ambient temperature

4: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 30 h / Ambient temperature

5: 99 percent / triphenylphosphine dibromide / CH₂Cl₂ / 28 °C

6: methanesulfonic acid / 20 °C

7: Et₃N, Ac₂O / dimethylformamide / 1 h / 37 °C

8: 4 N HCl / acetone / Ambient temperature

9: 1 M sodium hypochlorite / ethyl acetate / 4 h / Ambient temperature

10: Zn, AcOH

11: 74 percent / H₂, HCl / 10percent Pd/C / tetrahydrofuran; H₂O / 30 h / 2585.7 Torr

12: sodium bis-(2-methoxyethoxy)aluminium hydride / toluene / 1 h / 20 °C

13: 80 percent / MnO₂ / toluene / 2 h

With hydrogenchloride; manganese(IV) oxide; sodium hypochlorite; sodium tetrahydroborate; methanesulfonic acid; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen; acetic anhydride; acetic acid; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; zinc; sodium nitrite; dibromotriphenylphosphorane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/jhet.5570290223