2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Base Information

Chemical Name:2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole
CAS No.:1370346-54-5
Molecular Formula:C₂₁H₂₃N₅O₄S₃
Molecular Weight:505.643
Hs Code.:

Synonyms:2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

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Chemical Property of 2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

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Technology Process of 2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

There total 5 articles about 2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1370346-36-3
2-(p-methylphenylaminosulfonylmethyl)-5-[Z-(p-methylstyrylsulfonylmethyl)]-1,3,4-thiadiazole

: 1370346-54-5
2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: With triethylamine; In diethyl ether; dichloromethane; at -20 - -15 ℃; for 48h;
DOI:10.1248/cpb.59.1509

Reference yield:

: 1136056-24-0
C₁₀H₁₃NO₄S

: 1370346-54-5
2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; hydrazine hydrate / methanol / Reflux

2: trichlorophosphate / Reflux

3: thiourea / tetrahydrofuran / 120 - 130 °C

4: triethylamine / diethyl ether; dichloromethane / 48 h / -20 - -15 °C

With pyridine; hydrazine hydrate; triethylamine; thiourea; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1248/cpb.59.1509

Reference yield:

: 1370346-31-8
C₉H₁₃N₃O₃S

: 1370346-54-5
2-(p-methylphenylaminosulfonylmethyl)-5-(4-(p-methylphenyl)-4,5-dihydro-1H-pyrazol-3-ylsulfonylmethyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / Reflux

2: thiourea / tetrahydrofuran / 120 - 130 °C

3: triethylamine / diethyl ether; dichloromethane / 48 h / -20 - -15 °C

With triethylamine; thiourea; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1248/cpb.59.1509