2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester
• CAS No.: 145006-90-2
• Molecular Formula: C₁₆H₁₆BrNO₄S
• Molecular Weight: 398.277
• Mol file: 145006-90-2.mol

Synonyms:2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester

Chemical Property of 2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester

There total 1 articles about 2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Bromophenethylamine (73918-56-6) + 2-methoxycarbonylbenzenesulfonyl chloride (26638-43-7) → 2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester (145006-90-2)

Guidance literature:

With pyridine; In chloroform; Ambient temperature;

DOI:10.1021/jm00102a016

Reference yield: 78.0%

2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester (145006-90-2) → 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide (145006-28-6)

Guidance literature:

With pyridine; dmap; In xylene; for 25h; Heating;

DOI:10.1021/jm00102a016

Reference yield:

2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester (145006-90-2) → C18H15BrN2O4S

Guidance literature:

Multi-step reaction with 6 steps

1: 78 percent / 4-(dimethylamino)pyridine, pyridine / xylene / 25 h / Heating

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: acetic anhydride / 0.83 h / Heating

4: dimethylsulfoxide / 1.42 h / Ambient temperature

5: 1.) hydrogen chloride / 1.) RT, 5 d, 2.) reflux, 4 h

6: acetic acid / 4 h / Heating

With pyridine; hydrogenchloride; dmap; potassium tert-butylate; acetic anhydride; In acetic acid; dimethyl sulfoxide; xylene;

DOI:10.1021/jm00102a016

upstream raw materials:

4-Bromophenethylamine

2-methoxycarbonylbenzenesulfonyl chloride

Downstream raw materials:

2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide

3-{2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-phenyl}-2-cyano-3-oxo-propionic acid ethyl ester

C₂₀H₁₇BrN₂O₆S

{2-[2-(4-Bromo-phenyl)-ethyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester