4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

Base Information

Chemical Name:4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol
CAS No.:165404-63-7
Molecular Formula:C₁₉H₂₆N₄O₂S₃Si
Molecular Weight:466.725
Hs Code.:

Synonyms:4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

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Chemical Property of 4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

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Technology Process of 4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

There total 4 articles about 4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.5%

: 52431-78-4
1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol

: 165404-83-1
3-[(tert-butyldimethylsilyloxy)methyl]-6-(hydroxymethyl)-1,2-dithiin

: 165404-63-7
4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 5 ℃; for 1h;
DOI:10.1021/jm00014a016

Reference yield:

: 2,5-bis<(2-cyanoethyl)thio>-2,4-hexadiene-1,6-diol

: 165404-63-7
4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 49.3 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) t-BuOK, 2.) aq. K₃FeCN₆ / 1.) eter, 11 min, 2.) eter, 12 min

3: 51.5 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 5 °C

With 1H-imidazole; potassium tert-butylate; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a016

Reference yield:

: 1-<(tert-butyldimethylsilyl)oxy>-2,5-bis<(2-cyanoethyl)thio>-2,4-hexadien-6-ol

: 165404-63-7
4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK, 2.) aq. K₃FeCN₆ / 1.) eter, 11 min, 2.) eter, 12 min

2: 51.5 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 5 °C

With potassium tert-butylate; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm00014a016