Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

Base Information

Chemical Name:Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid
CAS No.:80277-30-1
Molecular Formula:C₁₈H₁₈N₃O₅S₃*Na
Molecular Weight:475.546
Hs Code.:

Synonyms:Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

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Chemical Property of Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

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Technology Process of Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

There total 6 articles about Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 80277-31-2
2-(thien-2-ylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid phenyl ester

: 80277-30-1
Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

Guidance literature:: With hydrogenchloride; sodium hydroxide;

Reference yield:

: 27757-85-3
2-Aminomethylthiophene

: 80277-30-1
Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / 125 °C

2: 2N aq. NaOH / 2 h / Heating

With sodium hydroxide;
DOI:10.1021/jm00362a017

Reference yield:

: 61791-73-9
4,6-dichlorobenzene-1,3-disulfonyl chloride

: 80277-30-1
Sodium salt of 2-(2-thienylmethylamino)-4-(N-methylanilino)-5-sulfamoylbenzene sulfonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NH₃ / 1.) THF, 5-10 deg C, 2 h, 2.) MeOH, a) reflux, 10 min, b) RT, overnight

2: 53 percent / 6 h / 140 °C

3: 2 h / 125 °C

4: 2N aq. NaOH / 2 h / Heating

With sodium hydroxide; ammonia;
DOI:10.1021/jm00362a017