(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Base Information

Chemical Name:(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid
CAS No.:1313577-45-5
Molecular Formula:C₂₆H₂₄FN₃O₃S
Molecular Weight:477.559
Hs Code.:

Synonyms:(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

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Chemical Property of (S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

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Technology Process of (S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

There total 7 articles about (S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1313582-47-6
(S)-methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

: 1313577-45-5
(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Guidance literature:: (S)-methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1313577-45-5
(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

2: dibenzoyl peroxide / tetrachloromethane / 80 °C

3: triethylamine / toluene / Reflux

4: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

5: tetrahydrofuran / 20 °C

6: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With water; iron; sodium carbonate; ammonium chloride; triethylamine; lithium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1313577-45-5
(S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 16 h / Reflux

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

3: dibenzoyl peroxide / tetrachloromethane / 80 °C

4: triethylamine / toluene / Reflux

5: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux

6: tetrahydrofuran / 20 °C

7: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

With sulfuric acid; water; iron; sodium carbonate; ammonium chloride; triethylamine; lithium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;