(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

Base Information

Chemical Name:(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid
CAS No.:298208-78-3
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

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Technology Process of (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

There total 11 articles about (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium periodate (NaIO₄): sodium periodate (NaIO₄)

: 257296-73-4
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

: 298208-78-3
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

Guidance literature:: With sodium hydrogencarbonate; ruthenium(III)chloride; In tetrachloromethane; water; acetonitrile;

Reference yield:

: 257296-73-4
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

: 298208-78-3
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; In tetrachloromethane; water; acetonitrile; for 12h;
DOI:10.1021/jo991065r

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 298208-78-3
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzene / 0.5 h / 30 °C

2.1: BF₃*Et₂O / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 86 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 2 h / -78 °C

3.1: HCl / H₂O; ethyl acetate / 0.5 h

4.1: H₂O; ethyl acetate / 2 h

5.1: pyridine / CH₂Cl₂ / 12 h

6.1: tetrakis(triphenylphosphine)palladium⁽⁰⁾; potassium carbonate / acetonitrile / 24 h / Heating

7.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 20 h / 25 °C

7.2: 78 percent / sodium hydroxide; hydrogen peroxide / tetrahydrofuran; hexane; aq. ethanol / 0.5 h

8.1: NaHCO₃; NaIO₄; RuCl₃ / H₂O; acetonitrile; CCl₄ / 12 h

With pyridine; hydrogenchloride; ruthenium trichloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; water; ethyl acetate; acetonitrile; benzene; 1.1: olefination; Wittig reaction / 2.1: Reduction / 2.2: Reduction / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Acetylation / 6.1: Cyclization / 7.1: Addition / 7.2: Oxidation / 8.1: Oxidation;
DOI:10.1021/jo991065r