(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

Base Information

Chemical Name:(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline
CAS No.:257296-73-4
Molecular Formula:C₁₈H₂₅NO₂
Molecular Weight:287.402
Hs Code.:

Synonyms:(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

Chemical Property:

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Technology Process of (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

There total 10 articles about (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 7722-84-1
dihydrogen peroxide

: 280-64-8
9-bora-bicyclo[3.3.1]nonane

: 257296-67-6
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyl-5-vinyloxazoline

: 257296-73-4
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield: 78.0%

: 257296-67-6
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyl-5-vinyloxazoline

: 257296-73-4
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

Guidance literature:: (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyl-5-vinyloxazoline; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; hexane; at 25 ℃; for 20h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; ethanol; hexane; for 0.5h;
DOI:10.1021/jo991065r

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 257296-73-4
(4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzene / 0.5 h / 30 °C

2.1: BF₃*Et₂O / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 86 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 2 h / -78 °C

3.1: HCl / H₂O; ethyl acetate / 0.5 h

4.1: H₂O; ethyl acetate / 2 h

5.1: pyridine / CH₂Cl₂ / 12 h

6.1: tetrakis(triphenylphosphine)palladium⁽⁰⁾; potassium carbonate / acetonitrile / 24 h / Heating

7.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran; hexane / 20 h / 25 °C

7.2: 78 percent / sodium hydroxide; hydrogen peroxide / tetrahydrofuran; hexane; aq. ethanol / 0.5 h

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; potassium carbonate; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; acetonitrile; benzene; 1.1: olefination; Wittig reaction / 2.1: Reduction / 2.2: Reduction / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Acetylation / 6.1: Cyclization / 7.1: Addition / 7.2: Oxidation;
DOI:10.1021/jo991065r