1-isopropylcycloheptyl 4-cyanophenyl ketone

Base Information

Chemical Name:1-isopropylcycloheptyl 4-cyanophenyl ketone
CAS No.:851537-44-5
Molecular Formula:C₁₈H₂₃NO
Molecular Weight:269.387
Hs Code.:

Synonyms:1-isopropylcycloheptyl 4-cyanophenyl ketone

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Chemical Property of 1-isopropylcycloheptyl 4-cyanophenyl ketone

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Technology Process of 1-isopropylcycloheptyl 4-cyanophenyl ketone

There total 7 articles about 1-isopropylcycloheptyl 4-cyanophenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 851537-41-2
1-isopropylcycloheptyl 4-fluorophenyl ketone

: 143-33-9,25596-52-5
sodium cyanide

: 851537-44-5
1-isopropylcycloheptyl 4-cyanophenyl ketone

Guidance literature:: In N,N-dimethyl-formamide; at 150 ℃; for 48h;
DOI:10.1021/ol050104k

Reference yield:

: 851537-38-7
(4-fluoro-phenyl)-(1-isopropyl-cycloheptyl)-methanol

: 851537-44-5
1-isopropylcycloheptyl 4-cyanophenyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / PCC; Celite / CH₂Cl₂ / 20 °C

2: 83 percent / dimethylformamide / 48 h / 150 °C

With Celite; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol050104k

Reference yield:

: 60433-00-3
methyl cycloheptanecarboxylate

: 851537-44-5
1-isopropylcycloheptyl 4-cyanophenyl ketone

Guidance literature:: Multi-step reaction with 6 steps

1.1: iPr₂NH; nBuLi; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 2 h / -78 °C

1.2: tetrahydrofuran

2.1: LiAlH₄ / tetrahydrofuran / Heating

3.1: PCC; Celite / CH₂Cl₂

4.1: tetrahydrofuran / 2 h / 0 °C

5.1: 96 percent / PCC; Celite / CH₂Cl₂ / 20 °C

6.1: 83 percent / dimethylformamide / 48 h / 150 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; n-butyllithium; Celite; diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol050104k