3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

Base Information

Chemical Name:3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole
CAS No.:1449691-97-7
Molecular Formula:C₁₉H₁₈BrClN₂
Molecular Weight:389.722
Hs Code.:

Synonyms:3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

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Chemical Property of 3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

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Technology Process of 3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

There total 4 articles about 3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1449691-96-6
[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-yl]methanol

: 1449691-97-7
3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm400070u

Reference yield:

: C₁₃H₁₅ClO₃

: 1449691-97-7
3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / Inert atmosphere; Reflux

1.2: Reflux; Inert atmosphere

2.1: sodium hydride / mineral oil; toluene / 0.67 h / 20 - 60 °C / Inert atmosphere

2.2: 16 h / Reflux; Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

4.1: phosphorus tribromide / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; hydrazine hydrate; In diethyl ether; ethanol; dichloromethane; toluene; mineral oil;
DOI:10.1021/jm400070u

Reference yield:

: 1029295-67-7
ethyl 5-(4-chloro-3-methylphenyl)-1H-pyrazole-3-carboxylate

: 1449691-97-7
3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; toluene / 0.67 h / 20 - 60 °C / Inert atmosphere

1.2: 16 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3.1: phosphorus tribromide / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; In diethyl ether; dichloromethane; toluene; mineral oil;
DOI:10.1021/jm400070u