ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate
• CAS No.: 1449691-95-5
• Molecular Formula: C₂₁H₂₁ClN₂O₂
• Molecular Weight: 368.863
• Mol file: 1449691-95-5.mol

Synonyms:ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate

There total 2 articles about ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 5-(4-chloro-3-methylphenyl)-1H-pyrazole-3-carboxylate (1029295-67-7) + 4-Methylbenzyl bromide (104-81-4) → ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate (1449691-95-5)

Guidance literature:

ethyl 5-(4-chloro-3-methylphenyl)-1H-pyrazole-3-carboxylate; With sodium hydride; In toluene; mineral oil; at 20 - 60 ℃; for 0.666667h; Inert atmosphere;

4-Methylbenzyl bromide; In toluene; mineral oil; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/jm400070u

Reference yield:

C13H15ClO3 → ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate (1449691-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 2 h / Inert atmosphere; Reflux

1.2: Reflux; Inert atmosphere

2.1: sodium hydride / mineral oil; toluene / 0.67 h / 20 - 60 °C / Inert atmosphere

2.2: 16 h / Reflux; Inert atmosphere

With sodium hydride; hydrazine hydrate; In ethanol; toluene; mineral oil;

DOI:10.1021/jm400070u

Reference yield: 85.0%

ethyl 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxylate (1449691-95-5) → [5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-yl]methanol (1449691-96-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm400070u

upstream raw materials:

ethyl 5-(4-chloro-3-methylphenyl)-1H-pyrazole-3-carboxylate

4-Methylbenzyl bromide

Downstream raw materials:

[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-yl]methanol

3-(bromomethyl)-5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole

[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-yl]methyl-triphenylphosphonium bromide

5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide