cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

Base Information

Chemical Name:cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid
CAS No.:1011484-59-5
Molecular Formula:C₂₁H₃₀FNO₂
Molecular Weight:347.473
Hs Code.:

Synonyms:cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

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Chemical Property of cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

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Technology Process of cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

There total 1 articles about cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1011484-53-9
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarbonitrile

: 1011484-59-5
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

Guidance literature:: With sulfuric acid; acetic acid; In water; for 3h; Heating;
DOI:10.1021/jm7009606

Reference yield: 32.0%

: 1011484-59-5
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

: 100-46-9
benzylamine

: 1011484-71-1
cis-N-benzyl-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxamide

Guidance literature:: cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid; With thionyl chloride; at 20 ℃;

benzylamine; With pyridine; at 20 ℃; Further stages.;
DOI:10.1021/jm7009606

Reference yield: 28.0%

: 1011484-59-5
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid

: 593-51-1
methylamine hydrochloride

: 1011484-65-3
cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-N-methyl-4-piperidinecarboxamide

Guidance literature:: cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarboxylic acid; With thionyl chloride; at 20 ℃;

methylamine hydrochloride; With pyridine; diisopropylamine; at 20 ℃; Further stages.;
DOI:10.1021/jm7009606