4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol

Base Information

• Chemical Name: 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol
• CAS No.: 198064-70-9
• Molecular Formula: C₁₉H₂₂ClN₃O₂
• Molecular Weight: 359.856
• Mol file: 198064-70-9.mol

Synonyms:4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol

Chemical Property of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol

There total 9 articles about 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-hexanoic acid ethyl ester (198064-68-5) → 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol (198064-70-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1248/cpb.51.565

Reference yield:

ethyl 8-chloro-8-oxooctanoate (14113-02-1) → 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol (198064-70-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent / AlCl₃ / 20 °C

2: Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / Heating

4: pyridine / tetrahydrofuran / 20 °C

5: 87 percent / NH₄OAc; AcOH / Heating

6: 70 percent / POCl₃; pyridine / 125 °C

7: 87 percent / K₂CO₃ / dimethylformamide / 120 - 130 °C

8: 90 percent / LAH / tetrahydrofuran / 0 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;

DOI:10.1248/cpb.51.565

Reference yield:

chlorobenzene (108-90-7) → 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolehexanol (198064-70-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent / AlCl₃ / 20 °C

2: Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / Heating

4: pyridine / tetrahydrofuran / 20 °C

5: 87 percent / NH₄OAc; AcOH / Heating

6: 70 percent / POCl₃; pyridine / 125 °C

7: 87 percent / K₂CO₃ / dimethylformamide / 120 - 130 °C

8: 90 percent / LAH / tetrahydrofuran / 0 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;

DOI:10.1248/cpb.51.565

upstream raw materials:

6-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-hexanoic acid ethyl ester

ethyl 8-chloro-8-oxooctanoate

chlorobenzene

ethyl 8-(4-chlorophenyl)-8-oxooctanoate

Refernces