1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

Base Information

Chemical Name:1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole
CAS No.:882043-82-5
Molecular Formula:C₃₀H₃₃F₂NO₅SSi
Molecular Weight:585.744
Hs Code.:

Synonyms:1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

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Chemical Property of 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

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Technology Process of 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

There total 7 articles about 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 943524-16-1
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

: 124-63-0
methanesulfonyl chloride

: 882043-82-5
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4.5h;
DOI:10.1139/V07-020

Reference yield:

: 882043-76-7
1-[2'-deoxy-3',5'-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-4,6-difluoroindole

: 882043-82-5
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / MeONa; methanol / 2 h / 20 °C

2: 88 percent / pyridine / 24 h / 20 °C

3: 99 percent / pyridine / CH₂Cl₂ / 4.5 h / 20 °C

With pyridine; methanol; sodium methylate; In dichloromethane;
DOI:10.1139/V07-020

Reference yield:

: 882043-79-0
1-(2'-deoxy-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

: 882043-82-5
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / 24 h / 20 °C

2: 99 percent / pyridine / CH₂Cl₂ / 4.5 h / 20 °C

With pyridine; In dichloromethane;
DOI:10.1139/V07-020