N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Base Information

Chemical Name:N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide
CAS No.:1227263-79-7
Molecular Formula:C₃₃H₃₅ClN₆O₃S
Molecular Weight:631.198
Hs Code.:

Synonyms:N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

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Chemical Property of N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

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Technology Process of N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

There total 13 articles about N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1227263-97-9
4-chloro-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazoline

: 2-amino-N-(2-chloro-6-methylphenyl)benzo[d]thiazole-6-carboxamide

: 1227263-79-7
N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: 2-amino-N-(2-chloro-6-methylphenyl)benzo[d]thiazole-6-carboxamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

4-chloro-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazoline; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.03.013

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1227263-79-7
N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(ll) sulfate pentahydrate / methanol / 6 h / Reflux

2.1: dmap / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 6 h / 0 - 10 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C

7.2: 12 h / 20 °C

With dmap; copper(ll) sulfate pentahydrate; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.013

Reference yield:

: 50850-93-6
ethyl 2-aminobenzothiazole-6-carboxylate

: 1227263-79-7
N-(2-chloro-6-methylphenyl)-2-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 6 h / 0 - 10 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C

6.2: 12 h / 20 °C

With dmap; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.013