6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

Base Information

Chemical Name:6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile
CAS No.:109492-96-8
Molecular Formula:C₂₁H₂₃NO₅S
Molecular Weight:401.483
Hs Code.:

Synonyms:6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

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Chemical Property of 6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

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Technology Process of 6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

There total 10 articles about 6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 109492-95-7
6-(4-benzyloxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

: 109492-96-8
6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 109492-96-8
6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

Guidance literature:: Multi-step reaction with 11 steps

1: HCl

2: 96.5 percent / sodamide / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

3: 32 g / AlCl₃ / benzene / 7 h / Heating

4: 82 percent / K₂CO₃, KI / butan-2-one / Heating

5: 80 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 1 h / -33 °C

6: 83 percent / 2M-NaOH / ethanol / 0.67 h / Heating

7: 98 percent / thionyl chloride / Ambient temperature

8: 91 percent / 1.) Mg; 2.) CdCl₂ / 1.) ether, reflux, 1 h; 2.) rt., l5 min then benzene, reflux, 1 h

9: 32 percent / ozone / CH₂Cl₂ / 0.08 h / -78 °C

10: 50 percent / tetrahydrofuran / 10 h / Ambient temperature

11: 100 percent / BCl₃ / CH₂Cl₂ / -78 °C

With hydrogenchloride; sodium hydroxide; aluminium trichloride; thionyl chloride; boron trichloride; potassium carbonate; ozone; sodium amide; magnesium; potassium iodide; cadmium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; ammonia; butanone; benzene;

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 109492-96-8
6-(4-hydroxyphenyl)-6-methyl-5-oxo-2-(p-tolylsulphonyloxy)heptanonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: 96.5 percent / sodamide / liquid ammonia; tetrahydrofuran / 1 h / -33 °C

2: 32 g / AlCl₃ / benzene / 7 h / Heating

3: 82 percent / K₂CO₃, KI / butan-2-one / Heating

4: 80 percent / NaNH₂ / tetrahydrofuran; liquid ammonia / 1 h / -33 °C

5: 83 percent / 2M-NaOH / ethanol / 0.67 h / Heating

6: 98 percent / thionyl chloride / Ambient temperature

7: 91 percent / 1.) Mg; 2.) CdCl₂ / 1.) ether, reflux, 1 h; 2.) rt., l5 min then benzene, reflux, 1 h

8: 32 percent / ozone / CH₂Cl₂ / 0.08 h / -78 °C

9: 50 percent / tetrahydrofuran / 10 h / Ambient temperature

10: 100 percent / BCl₃ / CH₂Cl₂ / -78 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; boron trichloride; potassium carbonate; ozone; sodium amide; magnesium; potassium iodide; cadmium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; ammonia; butanone; benzene;