Technology Process of 3-<(17S)-3-Hydroxyestra-1,3,5(10)-trien-17-yloxy>-1-propyl benzoate
There total 5 articles about 3-<(17S)-3-Hydroxyestra-1,3,5(10)-trien-17-yloxy>-1-propyl benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
palladium on activated charcoal;
In
ethyl acetate;
for 16h;
under 760 Torr;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / K2CO3 / ethanol / 6 h / Heating
2: 67 percent / p-TsOH*H2O, Na2SO4, molecular sieves 3 Angstroem / toluene / 22 h / Heating
3: 92 percent / H3B*SMe2, F3CSO3SiMe3 / CH2Cl2; tetrahydrofuran / 1.5 h / -78 °C
4: 90 percent / DMAP, pyridine / 1.) 0 deg C, 30 min, 2.) r.t., 3.5 h
5: 94 percent / H2 / 10percent Pd/C / ethyl acetate / 16 h / Ambient temperature
With
pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; 3 A molecular sieve; hydrogen; potassium carbonate; toluene-4-sulfonic acid; sodium sulfate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / p-TsOH*H2O, Na2SO4, molecular sieves 3 Angstroem / toluene / 22 h / Heating
2: 92 percent / H3B*SMe2, F3CSO3SiMe3 / CH2Cl2; tetrahydrofuran / 1.5 h / -78 °C
3: 90 percent / DMAP, pyridine / 1.) 0 deg C, 30 min, 2.) r.t., 3.5 h
4: 94 percent / H2 / 10percent Pd/C / ethyl acetate / 16 h / Ambient temperature
With
pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; 3 A molecular sieve; hydrogen; toluene-4-sulfonic acid; sodium sulfate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
