dexamethasone 21-glucoside

Base Information

• Chemical Name: dexamethasone 21-glucoside
• CAS No.: 88158-43-4
• Molecular Formula: C₂₈H₃₉FO₁₀
• Molecular Weight: 554.61
• Mol file: 88158-43-4.mol

Synonyms:dexamethasone 21-glucoside

Chemical Property of dexamethasone 21-glucoside

Chemical Property:

• Vapor Pressure: 5.1E-28mmHg at 25°C
• Boiling Point: 778.9°C at 760 mmHg
• Flash Point: 424.8°C
• PSA: 173.98000
• Density: 1.45g/cm³
• LogP: -0.28010

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dexamethasone 21-glucoside

There total 3 articles about dexamethasone 21-glucoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxapregna-1,4-dien-21-yl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (88158-45-6) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxapregna-1,4-dien-21-yl β-D-glucopyranoside (88158-43-4,319426-57-8)

Guidance literature:

With sodium hydroxide; In methanol; benzene; for 0.75h; Ambient temperature;

DOI:10.1021/jm00369a005

Reference yield:

dexamethasone (50-02-2) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxapregna-1,4-dien-21-yl β-D-glucopyranoside (88158-43-4,319426-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / Ag₂CO₃ / CCl₄; dioxane / 1 h / Heating; 4A molecular sieves

2: 75 percent / 0.04 N NaOH / methanol; benzene / 0.75 h / Ambient temperature

With sodium hydroxide; silver carbonate; In 1,4-dioxane; methanol; tetrachloromethane; benzene;

DOI:10.1021/jm00369a005

Reference yield:

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxapregna-1,4-dien-21-yl β-D-glucopyranoside (88158-43-4,319426-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / Ag₂CO₃ / CCl₄; dioxane / 1 h / Heating; 4A molecular sieves

2: 75 percent / 0.04 N NaOH / methanol; benzene / 0.75 h / Ambient temperature

With sodium hydroxide; silver carbonate; In 1,4-dioxane; methanol; tetrachloromethane; benzene;

DOI:10.1021/jm00369a005

upstream raw materials:

9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxapregna-1,4-dien-21-yl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

dexamethasone

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

Refernces