Welcome to LookChem.com Sign In|Join Free
  • or

50-02-2

Post Buying Request

50-02-2 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
High quality Dexamethasone with best price and good quality cas:50-02-2
Cas No: 50-02-2
USD $ 550.0-800.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Hot sale Dexamethasone with most affordable price
Cas No: 50-02-2
USD $ 700.0-800.0 / Gram 10 Gram 1-100 Kilogram/Day Wuhan Zenuo Biological Medicine Technology Co Ltd Contact Supplier
Dexamethasone in stock CAS 50-02-2
Cas No: 50-02-2
No Data 1 Kilogram 10 Metric Ton/Month Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
Hot sale Dexamethasone 99% low price
Cas No: 50-02-2
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
high quality EP/USP dexamethasone
Cas No: 50-02-2
No Data 1 Kilogram 10000 Kilogram/Month SHINING HEALTH GROUP LIMITED Contact Supplier
Dexamethasone
Cas No: 50-02-2
USD $ 10.0-10.0 / Kilogram 1 Kilogram 100 Kilogram/Month Antimex Chemical Limied Contact Supplier
99%min Corticosteroid Powder Dexamethasone CAS 50-02-2 For Anti Inflammatory
Cas No: 50-02-2
No Data 10 Gram 10000 Metric Ton/Month Hubei XinRunde Chemical Co., Ltd Contact Supplier
Dexamethasone 50-02-2
Cas No: 50-02-2
USD $ 600.0-600.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Wuhan Ying Yuan Bei Biological Limited Contact Supplier
High Quality Dexamethasone Powder
Cas No: 50-02-2
USD $ 0.1-0.2 / Kilogram 1 Kilogram 1000 Kilogram/Month Binbo Biological Co., Ltd Contact Supplier
Dexamethasone Manufacturer/High quality/Best price/In stock
Cas No: 50-02-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier

50-02-2 Usage

Brand name

Aeroseb-Dex (Allergan); Decadron (Merck); Dexone (Solvay Pharmaceuticals); Hexadrol (Organon); Maxidex (Alcon); Mymethasone (Morton Grove).

Fire Hazard

Flash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.

Reactivity Profile

Dexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.

General Description

Odorless white to off-white crystalline powder with a slightly bitter taste.

Side Effects

Dexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include:
It can cause stomach discomfort and increased sensitivity to stomach ulcers.
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Biological Activity

Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.

Uses

Glucocorticoid.

Description

Dexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cd k2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Dexamethasone regulates T cell survival, growth, and differentiation.Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.

Air & Water Reactions

Insoluble in water.

Purification Methods

Dexamethasone has been recrystallised from Et2O or small volumes of EtOAc. Its solubility in H2O is 10 mg/100mL at 25o; and is freely soluble in Me2CO, EtOH and CHCl3. [Arth et al. J Am Chem Soc 80 3161 1958; for the -methyl isomer see Taub et al. J Am Chem Soc 82 4025 1960, see Beilstein 8 IV 3501.]

Drug Reactions

Dexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Amphotericin
Aspirin
Cyclophosphamide
Cyclosporine
Digoxin
Daunorubicin HCl
Doxorubicin HCl
Insulin
Mitotane
Phenobarbital
Phenytoin sodium
Rifampin
Rimadyl
InChI:InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1

50-02-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (D1756)  Dexamethasone  ≥98% (HPLC), powder 50-02-2 D1756-5G 14,419.08CNY Detail
Sigma (D1756)  Dexamethasone  ≥98% (HPLC), powder 50-02-2 D1756-1G 3,958.11CNY Detail
Sigma (D1756)  Dexamethasone  ≥98% (HPLC), powder 50-02-2 D1756-500MG 2,517.84CNY Detail
Sigma (D1756)  Dexamethasone  ≥98% (HPLC), powder 50-02-2 D1756-100MG 1,351.35CNY Detail
Sigma (D1756)  Dexamethasone  ≥98% (HPLC), powder 50-02-2 D1756-25MG 600.21CNY Detail
Sigma-Aldrich (Y0001177)  Dexamethasone for system suitability  European Pharmacopoeia (EP) Reference Standard 50-02-2 Y0001177 1,880.19CNY Detail
Sigma-Aldrich (Y0001593)  Dexamethasone for peak identification  European Pharmacopoeia (EP) Reference Standard 50-02-2 Y0001593 1,880.19CNY Detail
Alfa Aesar (A17590)  Dexamethasone, 98%    50-02-2 25g 5377.0CNY Detail
Alfa Aesar (A17590)  Dexamethasone, 98%    50-02-2 5g 1811.0CNY Detail
Alfa Aesar (A17590)  Dexamethasone, 98%    50-02-2 1g 881.0CNY Detail

50-02-2Downstream Products

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields