methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

Base Information

• Chemical Name: methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
• CAS No.: 81564-98-9
• Molecular Formula: C₁₇H₁₆ClNO₃S
• Molecular Weight: 349.838

Synonyms:methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

Chemical Property of methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

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Technology Process of methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

There total 1 articles about methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-(methylthio)benzoyl chloride (1442-06-4) + methyl 6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (81564-88-7) → methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (81564-98-9)

Guidance literature:

In xylene; for 63h; Heating;

DOI:10.1021/jm00388a013

Reference yield: 87.0%

methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (81564-98-9) → 6-Chloro-5-(4-methylsulfanyl-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (81565-03-9)

Guidance literature:

With potassium carbonate; In methanol; water; for 1.5h; Heating;

DOI:10.1021/jm00388a013

Reference yield: 60.0%

methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (81564-98-9) → methyl 5-<4-(methylsulfonyl)benzoyl>-6-chloro-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate (81565-06-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.666667h;

DOI:10.1021/jm00388a013

upstream raw materials:

4-(methylthio)benzoyl chloride

methyl 6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

Downstream raw materials:

6-Chloro-5-(4-methylsulfanyl-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

methyl 5-<4-(methylsulfonyl)benzoyl>-6-chloro-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

5-p-methylsulfonylbenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

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